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LuciBet (Bictegravir EmtricitabineTenofovir Alafenamide)
HomeHIV CARE LuciBet Bictegravir EmtricitabineTenofovir Alafenamide Tablets
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LuciBet Bictegravir EmtricitabineTenofovir Alafenamide Tablets

$55

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Category: HIV CARE Tag: HIV-1 infection
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Description

LuciBet Bictegravir EmtricitabineTenofovir Alafenamide Tablets

LuciBet is a fixed-dose combination tablet containing three antiretroviral agents: bictegravir (50 mg), emtricitabine (200 mg), and tenofovir alafenamide (25 mg). This combination is primarily used for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 25 kg. By targeting different stages of the HIV replication cycle, LuciBet offers a potent regimen to suppress viral load and maintain immune function.

What is LuciBet?

LuciBet is a generic version of the branded drug Biktarvy, developed by Gilead Sciences. It combines three antiretroviral drugs:

  • By inhibiting the HIV-1 integrase enzyme, bictegravir, an integrase strand transfer inhibitor (INSTI), stops viral DNA from integrating into host cells.
  • Emtricitabine: A nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-1 reverse transcriptase, leading to premature termination of viral DNA synthesis.
  • Tenofovir Alafenamide: A prodrug of tenofovir, an NRTI, that is converted intracellularly to tenofovir, which then inhibits reverse transcriptase and causes chain termination during DNA synthesis.

Mechanism of Action

Each component of LuciBet targets a specific step in the HIV replication cycle:

  • Bictegravir: Inhibits the strand transfer activity of HIV-1 integrase, preventing the integration of viral DNA into the host genome. 
  • Emtricitabine: Acts as a chain-terminating nucleoside analog, inhibiting reverse transcriptase and preventing viral DNA synthesis. 
  • Tenofovir Alafenamide: Converted to tenofovir intracellularly, which inhibits reverse transcriptase and leads to chain termination during DNA synthesis. 
  • Indications

LuciBet is indicated for:

  • HIV-1 infection treatment for children and adults weighing 25 kg or more.
  • Use as a complete regimen for the treatment of HIV-1 infection, not to be used with other antiretroviral agents.

Dosage and Administration

Adults and Pediatric Patients ≥25 kg: One tablet (50 mg bictegravir/200 mg emtricitabine/25 mg tenofovir alafenamide) taken orally once daily with or without food. 

Side Effects

Common side effects may include:

  • Headache
  • Diarrhea
  • Nausea
  • Fatigue

Serious side effects can include:

  • Liver problems
  • Kidney problems
  • Bone problems
  • Immune reconstitution inflammatory syndrome (IRIS)

Storage

Keep LuciBet firmly sealed in its original container at or below 30°C (86°F). The desiccant packet should not be taken out of the bottle. 

Benefits

LuciBet offers several benefits:

  • Once-daily dosing improves adherence.
  • Fixed-dose combination reduces pill burden.
  • High barrier to resistance.
  • Well-tolerated with a favorable side effect profile.

Prescription

LuciBet is a prescription medication and should be used under the supervision of a healthcare provider. Regular monitoring of kidney function, liver enzymes, and bone mineral density is recommended during treatment.

Drug Interactions

LuciBet may interact with other medications, including:

  • Magnesium or aluminum-containing antacids should be taken at least two hours prior to LuciBet or six hours following it.
  • Iron or calcium-containing supplements or antacids (which should be taken with food concurrently with LuciBet).
  • Bicentegravir levels may be impacted by medications that stimulate or inhibit the CYP3A or UGT1A1 enzymes. 

FAQs

Can LuciBet cure HIV?

No, LuciBet does not cure HIV but helps to control the virus and maintain a low viral load.

Can LuciBet cause side effects?

Yes, common side effects include headache, nausea, and diarrhea, but serious effects are rare.

Conclusion

LuciBet is an effective and convenient treatment option for managing HIV-1 infection. Its once-daily dosing and fixed-dose combination simplify treatment regimens, improving patient adherence. Regular monitoring and consultation with a healthcare provider are essential to ensure optimal outcomes.

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