uciElo 25mg, Eltrombopag Tablets

LuciElo 25mg, containing the active ingredient Eltrombopag, is a specialized medication used primarily to manage conditions associated with low platelet counts. It plays a critical role in stimulating platelet production in patients with certain chronic blood disorders. Manufactured with precision, LuciElo 25mg is a valuable therapeutic option in hematology and oncology, particularly for patients suffering from chronic immune thrombocytopenia (ITP) and other platelet-related conditions.

What is LuciElo 25mg?

Eltrombopag olamine, a thrombopoietin receptor agonist (TPO-RA), is an ingredient in the prescription oral medication LuciElo 25mg. In patients with severe aplastic anemia, hepatitis C-associated thrombocytopenia, and chronic ITP, it is recommended to raise platelet counts. This medication helps the bone marrow produce more platelets by imitating the body’s natural signals.

How Does LuciElo 25mg Work? (Mechanism of Action)

Eltrombopag, the active substance in LuciElo 25mg, acts by stimulating the thrombopoietin receptor (TPO-R), found on the surface of megakaryocyte precursors in the bone marrow.

Here’s how it works:

• Eltrombopag attaches itself to the TPO receptor (c-Mpl) and causes it to become active.
• Stimulates platelet production: This activation promotes the proliferation and differentiation of megakaryocytes (platelet precursors), leading to increased platelet production.
• Unlike natural thrombopoietin, it binds at a different site, allowing complementary action.
• This mechanism makes it effective in treating conditions where platelet production is abnormally low.

How to Use LuciElo 25mg / Indications

LuciElo 25mg is approved for use in the following conditions:

• Chronic Immune Thrombocytopenia (ITP): For individuals with chronic ITP who have not responded adequately to corticosteroids, immunoglobulins, or splenectomy, including adults and children aged ≥1 year.
• Thrombocytopenia in Chronic Hepatitis C: To allow the initiation and maintenance of interferon-based therapy in patients with chronic hepatitis C and low platelet counts.

Severe Aplastic Anemia (SAA):

• in adults who have not responded well enough to immunosuppressive treatment (IST).
• It is not used for emergency bleeding episodes but rather as a maintenance and supportive treatment.

How to Take LuciElo 25mg / Dosage

LuciElo 25mg is taken orally, with or without food. However, it must not be taken with dairy products, calcium-rich foods, or antacids containing aluminum, magnesium, or calcium, as these reduce its absorption.

General Dosing Guidelines:

 ITP (Adults):

• Starting dose: 50 mg once daily.
• Adjust according to platelet response.
• Maximum: 75 mg/day.

For Hepatitis C-associated thrombocytopenia:

• Starting dose: 25 mg once daily.
• Dose adjusted based on platelet count to maintain 50,000–200,000/μL.

For Severe Aplastic Anemia:

• Starting dose: 50 mg once daily.
• Adjust based on response and tolerance.

Note: For East Asian populations, the starting dose is usually lower (e.g., 25 mg/day) due to increased drug exposure.

Always follow your doctor’s advice and dosage recommendations.

Other Dosage Forms

LuciElo is available in various strengths:

• LuciElo 25mg

• LuciElo 50mg

These are chosen based on the severity of the condition, response to treatment, and patient-specific factors such as age, liver function, and comorbidities.

Side Effects

Like all medications, LuciElo 25mg may cause side effects. Most are manageable, but some may require medical attention.

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Tiredness or fatigue
• Cough or sore throat
• Muscle pain

Serious Side Effects:

• Liver function abnormalities (increased ALT/AST)
• Cataracts
• Blood clots (pulmonary embolism or deep vein thrombosis)
• Prolonged use may increase the risk of bone marrow fibrosis.
• Rebound thrombocytopenia after discontinuation
• Routine monitoring of liver function tests and complete blood count is required during therapy.

Storage

• Store at room temperature (20–25°C).
• Keep away from moisture, heat, and direct sunlight.
• Keep the bottle tightly closed.
• Do not use expired medication.
• Keep out of reach of children.

Benefits of LuciElo 25mg

• Boosts Platelet Count: Enables safer continuation of therapies that might otherwise be delayed due to low platelets.
• Oral Administration: Easy to take; improves patient compliance.
• Reduces Bleeding Risk: Especially in ITP patients.
• Allows Hepatitis C Treatment: Makes antiviral therapy possible in those with thrombocytopenia.
• Effective in Refractory Cases: Especially useful in SAA and patients unresponsive to standard therapies.

Prescription

LuciElo 25mg is a prescription-only medication. It should be used under the supervision of a qualified physician or hematologist. Dosing and duration depend on the patient’s condition and regular lab monitoring.

Drug Interactions

Eltrombopag interacts with several drugs and substances:

Major Interactions:

• Antacids, calcium supplements, dairy: Reduce absorption of the drug.
• Statins (e.g., rosuvastatin): Increased risk of side effects due to competition for liver enzymes.
• Hepatotoxic drugs: May increase the risk of liver damage.
• Cyclosporine: May affect drug levels.
• Avoid taking LuciElo within 4 hours of consuming calcium, iron, or magnesium supplements.

FAQs

Can LuciElo 25mg be taken with food?

Yes, but avoid dairy or calcium-rich foods within 4 hours before or after the dose.

How soon will LuciElo start working?

It may take 1–2 weeks to see a rise in platelet count, but full effects can take several weeks.

Is LuciElo a cure for ITP?

No, it helps manage symptoms by increasing platelet count, but it’s not a cure.

Conclusion

LuciElo 25mg (Eltrombopag) is a powerful oral medication designed to help manage chronic platelet deficiencies, particularly in challenging conditions like ITP, hepatitis C-associated thrombocytopenia, and severe aplastic anemia. With its targeted mechanism and oral convenience, it significantly improves the quality of life for patients struggling with low platelet counts. However, as with any potent drug, careful monitoring and professional supervision are essential to maximize its benefits and minimize risks.

If you or someone you know is dealing with a condition that affects platelet levels, LuciElo may offer a promising therapeutic avenue.