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HomeNSCLC LuciLorla 100mg, Lorlatinib Tablets
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LuciLorla 100mg, Lorlatinib Tablets

$265

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Category: NSCLC Tag: Non-Small Cell Lung Cancer (NSCLC)
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Description

LuciLorla 100mg, Lorlatinib Tablets

A targeted cancer treatment called LuciLorla 100mg, which contains Lorlatinib, was created to address particular genetic abnormalities linked to non-small cell lung cancer (NSCLC). As an advanced third-generation ALK (anaplastic lymphoma kinase) and ROS1 tyrosine kinase inhibitor, it plays a pivotal role in managing patients whose cancers have evolved resistance to earlier treatments.

What is LuciLorla 100mg?

LuciLorla 100mg is a formulation of Lorlatinib, primarily prescribed to treat ALK-positive or ROS1-positive metastatic NSCLC. Lorlatinib is a potent, brain-penetrant kinase inhibitor designed to tackle resistant tumors that have progressed after treatment with first- or second-generation ALK inhibitors like Crizotinib, Ceritinib, or Alectinib.

How It Works / Mechanism of Action

Lorlatinib binds to and targets the tyrosine kinases ROS1 and ALK. These enzymes are responsible for the growth and survival of certain cancer cells. In patients with ALK-positive or ROS1-positive NSCLC, genetic alterations cause these kinases to be abnormally active. Lorlatinib selectively inhibits these enzymes, disrupting cell signaling pathways, halting tumor growth, and inducing apoptosis (programmed cell death).

A significant advantage of Lorlatinib is its ability to penetrate the blood-brain barrier, making it effective in treating brain metastases, which are common in ALK-positive NSCLC patients.

How to Use / Indications

LuciLorla 100mg is used for:

  • Metastatic non-small cell lung cancer (NSCLC) in patients who are ALK-positive and whose disease has progressed after treatment with other ALK inhibitors.
  • Also indicated for patients with ROS1-positive NSCLC where other treatments may not be effective.
  • Treatment should always be initiated under the supervision of an oncologist experienced in using anticancer medications.

How to Take / Dosage

Standard Dosage:

  • The typical recommended dose is 100 mg orally once daily, with or without food.
  • The tablet should be swallowed whole and should not be crushed, chewed, or split.

Instructions:

  • Take it at the same time each day.
  • If a dose is missed and less than 4 hours have passed since the usual time, it may be taken. Otherwise, skip the missed dose and continue with the next one.
  • Avoid taking a double dose to make up for the missed one.

Other Dosage Forms or Strengths

Apart from the 100 mg tablet (LuciLorla 100mg), Lorlatinib may be available in 25 mg and 50 mg tablet forms, which are useful for dose modifications in case of side effects or specific patient requirements.

Dose Adjustments:

  • May be required in cases of hepatic or renal impairment.
  • Dose reduction or interruption may be necessary if serious adverse reactions occur.

Side Effects

Lorlatinib, like other potent targeted therapies, can have side effects. Not every patient will experience all of them, but it’s essential to monitor and manage them:

Common Side Effects:

  • Hypercholesterolemia and hypertriglyceridemia (elevated blood lipids)
  • Edema (swelling of limbs)
  • Peripheral neuropathy (numbness or tingling)
  • Cognitive and mood effects (confusion, mood changes, speech difficulties)
  • Fatigue
  • Diarrhea or constipation
  • Weight gain
  • Joint pain
  • Vision changes

Serious Side Effects:

  • CNS effects: hallucinations, seizures, cognitive impairment
  • Liver function abnormalities
  • Pneumonitis
  • QT prolongation (heart rhythm issue)
  • Patients should have regular lipid profile checks, ECGs, liver function tests, and neurological assessments during treatment.

Storage

  • Store at room temperature between 20°C to 25°C.
  • Protect from moisture and heat.
  • Keep in the original packaging to protect from light.
  • Keep out of reach of children and pets.

Benefits

  • Highly effective against resistant tumors: Especially in patients who have failed first- and second-line ALK inhibitors.
  • CNS penetration: One of the few ALK inhibitors effective against brain metastases.
  • Targeted therapy: Acts precisely on the mutated genes with minimal effect on normal cells, leading to better tolerance than traditional chemotherapy.
  • Convenient oral administration: Enhances patient compliance.

Prescription

  • LuciLorla 100mg is a prescription-only medicine, and treatment should be based on:
  • Positive identification of ALK or ROS1 rearrangements using FDA-approved diagnostic tests.
  • Monitoring by an oncology specialist to manage and adjust dosing based on clinical response and side effects.

Drug Interactions

CYP3A inhibitors and inducers:

  • Lorlatinib is metabolized via CYP3A4.
  • Avoid strong CYP3A inducers (e.g., rifampin, phenytoin, St. John’s wort) as they lessen the effectiveness of Lorlatinib.
  • Avoid strong CYP3A inhibitors (e.g., ketoconazole, grapefruit juice) which may increase toxicity.

Other interactions:

  • Drugs affecting heart rhythm (QT prolongation) should be used cautiously.
  • Co-administration with cholesterol-lowering drugs may be needed to manage hyperlipidemia.
  • Alcohol may increase CNS side effects.

Always provide your full medication list to your doctor before starting Lorlatinib.

FAQs 

Can LuciLorla 100mg cure cancer?

No, but it can significantly control and slow down ALK-positive or ROS1-positive NSCLC.

How long should LuciLorla be taken?

As long as it’s effective and well-tolerated, or until disease progression or unacceptable toxicity occurs.

Can I drink alcohol while on Lorlatinib?

Alcohol should be limited due to potential CNS side effects.

What if I experience mood or memory changes?

Report them immediately. Dose adjustments may be needed.

Conclusion

LuciLorla 100mg (Lorlatinib) represents a crucial step forward in precision oncology for ALK-positive and ROS1-positive NSCLC patients, particularly those with resistance to earlier therapies or brain metastases. Its superior efficacy, brain penetration, and manageable oral dosing make it a preferred option in its category. However, like all powerful therapies, it requires vigilant monitoring and should be prescribed by experienced oncologists.

Patients should be educated on potential side effects, interactions, and the importance of adherence to prescribed dosing and follow-ups. With careful management, LuciLorla offers hope and extended survival in a challenging cancer landscape.

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