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HomeKIDNEY / LIVER CARE LuciObe 5mg, Obeticholic acid Tablets
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LuciObe 5mg, Obeticholic acid Tablets

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Category: KIDNEY / LIVER CARE Tag: chronic liver disease
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Description

LuciObe 5mg, Obeticholic acid Tablets

Obeticholic Acid, a semi-synthetic bile acid analog, is present in LuciObe 5mg, a prescription medication. IPrimary Biliary Cholangitis (PBC), a chronic liver disease that eventually obliterates the liver’s bile ducts, is its main treatment. Manufactured under strict pharmaceutical standards, LuciObe provides a promising therapeutic option for patients unresponsive to first-line treatment or those requiring additional intervention. With growing clinical support, this drug has emerged as a vital advancement in hepatology.

What is LuciObe 5mg (Obeticholic Acid)?

LuciObe 5mg contains Obeticholic Acid, a modified form of the bile acid chenodeoxycholic acid that occurs naturally. It is an agonist of the Farnesoid X Receptor (FXR), which aids in controlling the production and movement of bile acids. Obeticholic acid is mainly indicated in the treatment of PBC, especially in patients who do not respond adequately to ursodeoxycholic acid (UDCA) or who cannot tolerate UDCA.

It is available in oral tablet form, with 5mg and 10mg dosages being the most commonly used strengths. LuciObe is marketed for its targeted action in reducing liver inflammation and preventing disease progression.

How It Works / Mechanism of Action

The Farnesoid X Receptor (FXR), a nuclear receptor mostly present in the liver and intestines, is activated by obetic acid. Bile acid equilibrium is maintained in large part by FXR. When activated:

  • It inhibits bile acid synthesis in the liver by suppressing the enzyme CYP7A1.
  • It enhances bile acid transport from the liver to the intestines.
  • It reduces hepatic inflammation and fibrosis, key factors in liver disease progression.
  • Through these mechanisms, LuciObe reduces the toxic effects of bile acid accumulation in liver cells, which is a hallmark of PBC.

How to Use / Indications

LuciObe 5mg is primarily indicated for:

Primary Biliary Cholangitis (PBC):

  • As monotherapy in patients intolerant to UDCA.
  • as supplemental treatment for people who don’t respond well to UDCA.
  • It may also be under clinical investigation for other cholestatic liver diseases and nonalcoholic steatohepatitis (NASH), although these uses are not yet FDA-approved.

How to Take / Dosage

Standard dosage for PBC:

  • Starting dose: 5 mg once daily.
  • If the 5 mg dose is well-tolerated but not effective enough after 3 months, the dose can be increased to 10 mg once daily.

Important Guidelines:

  • Take the medication at the same time each day.
  • Can be taken with or without food.
  • If a dose is missed, take it as soon as remembered unless it’s almost time for the next dose.

Always follow the healthcare provider’s specific instructions regarding dosage adjustment and monitoring.

Other Dosage Forms

In addition to 5mg, Obeticholic Acid is also available in:

  • 10 mg tablets, used in titration or for patients requiring higher therapeutic effect.
  • There are currently no injectable or liquid forms available. The dosing regimen may vary depending on the patient’s liver function and treatment goals.

Side Effects

Common side effects associated with LuciObe 5mg include:

  • Pruritus (itching) – most frequent, can be dose-dependent.
  • Fatigue
  • Abdominal pain
  • Rash
  • Arthralgia (joint pain)
  • Elevated cholesterol levels

Serious side effects (rare but possible):

  • Worsening of liver function
  • Hepatic decompensation (in advanced cirrhosis)
  • Jaundice
  • Ascites
  • Patients with Child-Pugh Class B or C cirrhosis must be monitored closely due to increased risk of liver failure.

Storage

Store LuciObe 5mg under the following conditions:

  • Temperature: Below 25°C (77°F)
  • Humidity: Keep in a dry place
  • Light: Store away from direct sunlight
  • Container: Keep in original packaging until use
  • Keep out of reach of children. Do not use expired medicine.

Benefits

LuciObe offers several benefits in the management of chronic liver diseases:

  • Delays disease progression in PBC patients.
  • Improves liver biochemical markers such as ALP (alkaline phosphatase) and bilirubin.
  • Can be used with UDCA for enhanced therapeutic effects.
  • Oral administration makes it easy and convenient.
  • Improves long-term survival in responsive patients.

Prescription

LuciObe 5mg is a prescription-only medication and should only be used under the supervision of a qualified healthcare professional.

Monitoring requirements include:

  • testing for liver function both before and after medication.
  • Lipid profile checks due to possible changes in HDL/LDL.
  • Adjustments based on response and tolerability.

Interaction

Obeticholic acid may interact with several medications:

Drug interactions include:

  • Warfarin – may affect INR levels, requiring closer monitoring.
  • Bile acid-binding resins (e.g., cholestyramine) – reduce LuciObe absorption; administer at least 4–6 hours apart.
  • CYP450 enzyme inhibitors/inducers – although metabolism is not highly CYP-dependent, caution is advised.
  • Statins: keep an eye out for any possible rise in liver enzymes.
  • Avoid concurrent use with drugs known to cause liver toxicity, unless deemed essential.

FAQs

Can LuciObe cure PBC?

No. LuciObe helps manage and slow disease progression, but it is not a cure.

When will I see improvements?

Biochemical improvements may be observed within 3 to 6 months of consistent therapy.

Can LuciObe be used for NASH?

It is under investigation for NASH, but not yet approved for that indication.

Conclusion

LuciObe 5mg (Obeticholic Acid) represents a significant development in the treatment of Primary Biliary Cholangitis, especially for patients not fully managed by UDCA. With its unique mechanism of action targeting the FXR pathway, it offers hope for improved biochemical response, reduced liver inflammation, and delayed disease progression.

However, due to potential side effects, particularly pruritus and hepatic complications in advanced liver disease, close monitoring is essential. Patients must use it only under medical supervision, following prescribed dosage and guidelines.

With expanding research, LuciObe may also find future applications in conditions like NASH, making it a potentially versatile option in hepatology.

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