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LuciSoVe (Sofosbuvir400mg+Velpatasvir100mg)
HomeKIDNEY / LIVER CARE LuciSoVe Sofosbuvir400mg+Velpatasvir100mg Tablets
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LuciSoVe Sofosbuvir400mg+Velpatasvir100mg Tablets

$55

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Category: KIDNEY / LIVER CARE Tag: chronic hepatitis C virus (HCV) infection
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Description

LuciSoVe Sofosbuvir400mg+Velpatasvir100mg Tablets

A fixed-dose combination antiviral drug called LuciSoVe contains 100 mg of Velpatasvir and 400 mg of Sofosbuvir. It is used to treat chronic hepatitis C virus (HCV) infection, a liver-related condition that can lead to cirrhosis, liver failure, or liver cancer if left untreated. This once-daily oral therapy represents a major advancement in the management of HCV due to its high cure rates across all genotypes.

What is LuciSoVe (Sofosbuvir + Velpatasvir)?

LuciSoVe is an antiviral medication belonging to the class of direct-acting antivirals (DAAs).It is used to treat chronic hepatitis C virus infections of all genotypes (1–6) in adults and some adolescents. Sofosbuvir and Velpatasvir act synergistically to inhibit two different proteins essential for the replication of the HCV.

How it Works / Mechanism of Action

The sofosbuvir, a nucleotide analog, inhibits the HCV NS5B polymerase. It gets converted into an active triphosphate form in the body, which mimics the natural nucleotides used by the virus. It is incorporated into the viral RNA and leads to chain termination, effectively stopping viral replication

Velpatasvir is an HCV NS5A inhibitor, a protein that is crucial for viral RNA replication and assembly. Inhibition of NS5A disrupts the life cycle of the virus at multiple stages.

Together, they offer a potent, pan-genotypic, once-daily oral regimen with a high barrier to resistance.

How to Use / Indications

LuciSoVe is indicated for the treatment of chronic hepatitis C virus (HCV) infection in adults and adolescents aged 12 years and above or weighing at least 35 kg, with or without compensated cirrhosis.

It is effective against all six major genotypes of HCV (1, 2, 3, 4, 5, and 6), which simplifies the treatment process by eliminating the need for genotype testing in many cases.

How to Take / Dosage

The suggested dosage is one pill (400 mg of sofosbuvir plus 100 mg of velpatasvir) taken once daily, with or without food.

Treatment Duration:

  • 12 weeks is the typical duration for most HCV-infected individuals, including those with cirrhosis (Child-Pugh A).
  • 24 weeks with ribavirin may be considered in patients with decompensated cirrhosis (Child-Pugh B or C).
  • Pediatric Use: The adult dosage schedule is applicable to adolescents who are 12 years of age or older and weigh more than 35 kg.
  • Important Note: Do not miss doses or stop taking LuciSoVe unless directed by your healthcare provider.

Other Dosage Information

LuciSoVe comes in a single fixed-dose combination. However, for special populations:

  • In patients with renal or hepatic impairment, dose adjustment is usually not required unless on dialysis or with severe liver dysfunction.
  • Co-administration with ribavirin may be necessary in some complicated cases like liver transplant recipients or decompensated cirrhosis.

Side Effects

Most people tolerate LuciSoVe well

Common side effects include:

  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Anemia (especially when combined with ribavirin)

Serious but rare side effects:

  • Bradycardia when used with amiodarone
  • Hepatic decompensation in advanced liver disease
  • Allergic reactions
  • Seek immediate medical attention if you notice signs of an allergic reaction such as rash, swelling, or difficulty breathing.

Storage

  • Store at room temperature (15°C to 30°C).
  • Protect from moisture and direct sunlight.
  • Keep in the original container until use.
  • Keep out of reach of children.

Benefits

  • Pan-genotypic: Works against all genotypes of HCV.
  • High cure rate: >95% sustained virological response (SVR).
  • Once-daily oral dose improves compliance.
  • Shorter duration of treatment (12 weeks for most).
  • Well-tolerated compared to older interferon-based regimens.
  • Useful for patients with compensated cirrhosis and HIV/HCV coinfection.

Prescription

LuciSoVe is a prescription-only medication. It should be used under the supervision of a qualified healthcare provider, ideally one experienced in the management of viral hepatitis. Regular monitoring of liver function, viral load, and drug interactions is essential during the course of treatment.

Drug Interactions

LuciSoVe may interact with several medications:

  • Amiodarone: May cause life-threatening bradycardia.
  • Antacids (e.g., aluminum or magnesium hydroxide): Can reduce Velpatasvir absorption.
  • HIV medications (e.g., efavirenz, tenofovir): May require dose monitoring or adjustment.
  • Rifampin, carbamazepine, St. John’s wort: Can reduce LuciSoVe effectiveness.
  • Avoid taking LuciSoVe with drugs that are potent P-gp or CYP inducers unless specifically directed by a physician.

FAQs

Can LuciSoVe cure hepatitis C completely?

Yes, it can cure HCV in over 95% of patients if taken correctly.

Can LuciSoVe be used in children?

Yes, in adolescents aged 12 years or weighing at least 35 kg.

Can it be used in patients with HIV?

Yes, but drug interaction management is crucial.

Conclusion

LuciSoVe (Sofosbuvir 400mg + Velpatasvir 100mg) is a revolutionary all-oral, pan-genotypic therapy for chronic HCV infection. Its simplified dosing, excellent tolerability, and high cure rates have made it a cornerstone in modern HCV treatment protocols. However, careful patient selection, monitoring, and awareness of drug interactions are vital to ensure safe and effective therapy. For optimal outcomes, LuciSoVe should be used under medical supervision, as part of a comprehensive hepatitis C management plan.

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