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LuciTrelag 100mg, (Trelagliptin)
HomeDIABETES LuciTrelag 100mg, Trelagliptin Tablets
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LuciTrelag 100mg, Trelagliptin Tablets

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Category: DIABETES Tag: type 2 diabetic mellitus
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Description

LuciTrelag 100mg, Trelagliptin Tablets

Trelagliptin is a once-weekly DPP-4 inhibitor that is part of the prescription oral drug LuciTrelag 100mg, which was created to treat type 2 diabetic mellitus (T2DM). Manufactured to aid in better glycemic control, LuciTrelag presents a convenient alternative to daily diabetes medications. By enhancing the body’s natural mechanisms for managing blood sugar levels, it supports a more manageable and compliant diabetes care routine, especially for patients seeking less frequent dosing.

What is LuciTrelag 100mg (Trelagliptin)?

LuciTrelag contains Trelagliptin succinate, a long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor. It is primarily used for once-weekly oral treatment of type 2 diabetes in adults, particularly when diet and exercise alone do not result in adequate glycemic control. Unlike other DPP-4 inhibitors that require daily intake (such as Sitagliptin or Saxagliptin), Trelagliptin’s long half-life allows weekly dosing, improving medication adherence.

How It Works / Mechanism of Action

Trelagliptin functions by inhibiting the DPP-4 enzyme, which is necessary for glucose metabolism. Here’s how it works:

  • The DPP-4 enzyme breaks down incretin hormones, specifically GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).
  • In response to meals, these incretin hormones cause the pancreatic β-cells to secrete more insulin and the α-cells to secrete less glucagon.
  • By inhibiting DPP-4, Trelagliptin increases the concentration of active incretins, thus improving postprandial and fasting glucose levels.
  • The once-weekly action is due to its long terminal half-life (~5 days), providing sustained DPP-4 inhibition.

How to Use / Indications

Indications:

Trelagliptin is used as monotherapy for adults with type 2 diabetes in one of two situations: 

  • when metformin is contraindicated or not tolerated.
  • In combination with other antidiabetic agents such as metformin, sulfonylureas, or insulin, when those alone do not provide adequate glycemic control.
  • Trelagliptin should not be used in type 1 diabetes or for treating diabetic ketoacidosis.

How to Take / Dosage

Standard Dosage:

  • The recommended dose of LuciTrelag is 100 mg once weekly, taken orally.
  • Although it can be taken with or without food, it is advised to take it on the same day each week for consistency.

Instructions:

  • Swallow the tablet whole with water.
  • If a week is missed, take it as soon as you remember, unless it’s almost time for the following dose.

Other Dosage Considerations

  • Renal Impairment: In mild to moderate cases, there is no need to change the dosage; however, in severe situations, care should be taken.
  • Hepatic Impairment: Limited data is available; use with caution.
  • Elderly Patients: Generally well tolerated, but monitor for renal function regularly.
  • Pediatrics: Due to a lack of safety data, it is not advised for children under the age of 18.

Side Effects

LuciTrelag is generally well tolerated. However, side effects may include:

Common Side Effects:

  • Nasopharyngitis (common cold-like symptoms)
  • Headache
  • Gastrointestinal upset (nausea, indigestion)

Less Common / Serious Side Effects:

  • Hypoglycemia (especially in conjunction with sulfonylureas or insulin)
  • Allergic reactions (rash, urticaria, swelling)
  • Elevated liver enzymes
  • Pancreatitis (rare but serious)

Monitoring Parameters:

  • Blood glucose levels
  • Liver function tests (periodically)
  • Renal function in elderly or compromised patients

Storage

  • Store at room temperature between 15°C to 30°C (59°F to 86°F).
  • Keep away from direct sunlight and moisture.
  • Keep out of reach of children.
  • Do not use after the expiry date mentioned on the package.

Benefits

  • Once-Weekly Dosing: Improves patient compliance and convenience.
  • Stable Glycemic Control: Maintains steady blood glucose levels.
  • Weight Neutral: Unlike some antidiabetic medications, it does not promote weight gain.
  • Minimal Risk of Hypoglycemia (in the absence of sulfonylureas or insulin).
  • Combination-Friendly: Can be used with other oral antidiabetics or insulin.

Prescription

  • LuciTrelag is a prescription-only medication.
  • It should only be prescribed by a qualified healthcare provider after assessment.
  • Regular follow-up is needed to monitor glycemic control and adjust therapy as required.

Interaction

Trelagliptin has a low potential for drug-drug interactions, but the following should be considered:

Potential Drug Interactions:

  • Sulfonylureas or Insulin: Increased risk of hypoglycemia.
  • Rifampin and other strong CYP3A4 inducers may reduce efficacy.
  • Renal excretion inhibitors: Can affect drug levels; monitor carefully.

No significant interaction with:

  • Metformin
  • Pioglitazone
  • Statins
  • Antihypertensives

Always inform your healthcare provider about all medications you are taking.

FAQs 

Is it for type 1 diabetes?

No, only for type 2 diabetes.

Will it cause low blood sugar?

Not usually, unless combined with insulin or sulfonylureas.

Can older adults take it?

Yes, but monitor kidney function regularly.

Can elderly patients take LuciTrelag?

Yes, but with renal function monitoring.

Conclusion

For individuals with type 2 diabetes, LuciTrelag 100mg (Trelagliptin), a new oral antidiabetic drug, provides convenient and efficient blood sugar control once weekly. By targeting the DPP-4 enzyme, it enhances the action of incretin hormones and thereby regulates insulin and glucagon levels in a glucose-dependent manner. Its favorable side effect profile, ease of use, and potential for combination therapy make it a valuable option, especially for patients looking for a simplified dosing schedule. However, regular monitoring and healthcare supervision are essential to ensure safety and effectiveness in long-term diabetes management.

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