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LuciVos 250 mg, (Ivosidenib)
HomeLEUKEMIA LuciVos 250mg, Ivosidenib Tablets
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LuciVos 250mg, Ivosidenib Tablets

$999

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Category: LEUKEMIA Tags: acute myeloid leukemia (AML), cholangiocarcinoma
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Description

LuciVos 250mg, Ivosidenib Tablets

LuciVos 250mg is a targeted cancer therapy that contains Ivosidenib, an oral, small-molecule inhibitor designed to block the activity of mutant isocitrate dehydrogenase 1 (IDH1). Manufactured under the brand LuciVos, this drug is a significant development in the treatment of certain types of cancers, especially acute myeloid leukemia (AML) and cholangiocarcinoma, where IDH1 mutations are identified. By selectively inhibiting mutant IDH1, Ivosidenib helps halt the abnormal cell growth linked with this genetic mutation.

What Is LuciVos 250mg (Ivosidenib)?

LuciVos 250mg is a prescription medication used to treat adults with:

  • Acute myeloid leukemia (AML) with a susceptible IDH1 mutation that has relapsed or is refractory.
  • Newly diagnosed AML, in patients ≥75 years old or who are ineligible for intensive chemotherapy.
  • Locally advanced or metastatic cholangiocarcinoma (bile duct cancer) with IDH1 mutations.
  • It is part of a class of medications called IDH1 inhibitors and works at a molecular level to correct the abnormal metabolic processes caused by these mutations.

How Does LuciVos Work? (Mechanism of Action)

Ivosidenib (LuciVos) targets and inhibits mutated IDH1 enzymes. In the Krebs cycle, IDH1 typically transforms isocitrate into α-ketoglutarate (α-KG). However, mutated IDH1 produces an oncometabolite called 2-hydroxyglutarate (2-HG) instead.

Excess 2-HG:

  • Interferes with cellular differentiation,
  • Promotes oncogenesis (cancer development), and
  • Inhibits normal hematopoietic development in AML.

By inhibiting the mutant enzyme, LuciVos:

  • Reduces 2-HG levels,
  • Restores normal cellular differentiation,
  • Slows down or halts tumor growth.

How to Use / Indications:

Adult patients with the following conditions are especially recommended to take LuciVos:

AML with IDH1 mutation:

  • Newly diagnosed AML: for patients unable to undergo intensive chemotherapy.
  • Relapsed or refractory AML: for those who have failed previous treatments.

Cholangiocarcinoma with IDH1 mutation:

  • Used after progression on at least one prior therapy.

Note: The presence of an IDH1 mutation must be confirmed via an FDA-approved test before initiating therapy.

How to Take / Dosage:

The standard recommended dose of LuciVos 250mg is:

  • AML: 500 mg once daily (two tablets of 250mg), taken with or without food.
  • Cholangiocarcinoma: 500 mg once daily until the condition worsens or the toxicity becomes intolerable.

Administration Tips:

  • Swallow tablets whole; do not crush, chew, or split.
  • Take at the same time each day.
  • Take a dosage as soon as you can if you miss it by less than 12 hours. If not, skip it and take the following dose as planned.

Other Dosage Forms / Adjustments:

  • LuciVos is currently available in 250mg tablets.
  • Dose modifications may be necessary in the case of:
  • QT prolongation
  • Differentiation syndrome
  • Severe hepatotoxicity
  • Other grade ≥3 adverse events
  • In such cases, the dose may be interrupted, reduced, or permanently discontinued based on clinical judgment and toxicity grading.

Side Effects:

Common Side Effects:

  • Fatigue
  • Nausea
  • Diarrhea or constipation
  • Joint pain
  • Shortness of breath
  • QT prolongation (heart rhythm problem)
  • Elevated liver enzymes (AST/ALT)

Serious Side Effects

Differentiation syndrome (can be life-threatening): presents as fever, dyspnea, weight gain, hypotension.

  • Tumor lysis syndrome (TLS)
  • Leukocytosis (elevated white blood cell count)
  • Cardiac arrhythmias
  • Anemia or thrombocytopenia
  • Blood counts, liver function tests, and ECGs should all be performed on a regular basis on patients.

Storage

Store LuciVos tablets at room temperature (20°C to 25°C).

  • Protect from excessive moisture and direct sunlight.
  • Keep in the original container and out of reach of children.
  • Do not use if the packaging is damaged or past the expiry date.

Benefits

  • Targeted Therapy: Specifically attacks cancer-causing mutations without broadly affecting healthy cells.
  • Oral Administration: Offers convenience compared to intravenous chemotherapy.
  • Improved Survival Rates: Clinical trials have shown improved outcomes in patients with IDH1-mutant cancers.
  • Well-Tolerated in Older Adults: Suitable for patients who are not eligible for standard chemotherapy.
  • Differentiation Restoration: Encourages malignant cells to mature and stop dividing uncontrollably.

Prescription

LuciVos 250mg is a prescription-only medicine. It must be prescribed by a healthcare professional experienced in treating cancer. The use of LuciVos is guided by genetic testing to identify eligible patients with IDH1 mutations. Routine monitoring and follow-up are mandatory during treatment.

Drug Interactions

LuciVos may interact with:

  • CYP3A4 inhibitors or inducers (e.g., ketoconazole, rifampin) :May alter Ivosidenib blood levels.
  • QT-prolonging drugs (e.g., amiodarone, methadone): Increases risk of cardiac arrhythmias.
  • Substrates of CYP3A4, CYP2C9, or CYP1A2
  • LuciVos may affect the metabolism of other drugs.
  • Avoid grapefruit juice and St. John’s Wort during treatment.

Always inform your doctor of all medications, supplements, and herbal products you are using.

FAQs

How long should I take LuciVos?

Until disease progression or unacceptable toxicity develops.

Is genetic testing required before taking LuciVos?

Yes, IDH1 mutation testing is mandatory to determine eligibility.

Does LuciVos affect fertility?

Potentially, yes. Discuss fertility preservation options with your oncologist before starting therapy.

Conclusion

LuciVos 250 mg(Ivosidenib) represents a major advancement in personalized cancer therapy. Designed to inhibit mutant IDH1 enzymes, it offers a tailored approach to managing certain aggressive cancers such as AML and cholangiocarcinoma. With a manageable side effect profile, oral dosing convenience, and molecular precision, LuciVos has become an essential tool in modern oncology—especially for patients with limited treatment options. However, it demands careful monitoring, patient education, and appropriate mutation testing before initiation. Always consult your oncologist for individualized guidance when considering or using LuciVos.

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