Dacilon 0.5 mg Injection (Dactinomycin)
Dacilon Injction 0.5mg (Dactinomycin), Dactinomycin is a cancer medication that interferes with the growth and spread of cancer cells in the body. Dactinomycin is used to treat different types of cancers that affect the kidneys, uterus, testicles, bones, muscles, joints, and soft tissues. Dacilon 0.5 mg is also used to treat solid tumors. Dactinomycin may also be used and some dactinomycin side effects
What is Dacilon 0.5 mg?
Dactinomycin is a cancer medication that interferes with the growth and spread of cancer cells in the body. Dactinomycin is used to treat different types of cancers that affect the kidneys, uterus, testicles, bones, muscles, joints, and soft tissues. Dactinomycin is also used to treat solid tumors. Dactinomycin may also be used for purposes not listed in this medication guide.
What is the most important information I should know about dactinomycin?
Dactinomycin is a cancer medication that interferes with the growth and spread of cancer cells in the body. You should not receive dactinomycin if you have recently had chickenpox or herpes zoster (shingles). Dacilon 0.5 mg can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
What should I discuss with my healthcare provider before receiving dactinomycin?
You should not receive Dacilon 0.5 mg if you are allergic to it, or if you have recently had chickenpox or herpes zoster (shingles). To make sure you can safely take dactinomycin, tell your doctor if you have recently received radiation treatment for Wilms tumor. Using dactinomycin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk. Do not use dactinomycin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether dactinomycin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dactinomycin.
How should I use Dacilon 0.5 mg?
Dactinomycin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Dactinomycin is usually given only on certain days during a treatment cycle. How often you receive this medication depends on the condition being treated. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when dactinomycin is injected. Dactinomycin can be harmful if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, rinse with plain water for at least 15 minutes. Dactinomycin can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
Call your doctor for instructions if you miss an appointment for your dactinomycin injection.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using dactinomycin?
Avoid getting this medicine on your clothes. Destroy any clothing the medicine has leaked onto if an accidental spill occurs. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient?s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry. Do not receive a ?live? vaccine while using dactinomycin, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Dactinomycin side effects
• Loss of appetite
• Glossitis (tongue inflammation)
• Lip inflammation
• Inflammation of the rectum
• Low blood platelets
Dacilon 0.5 mg dosing information
Usual Adult Dose for Wilms? Tumor:
15 mcg/kg/day or 400 to 600 mcg/m2/day intravenously for 5 days as a part of a combination regimen. Dosage for obese or edematous adult patients may be calculated on the basis of body surface area to relate dosage to lean body mass. Dosage may be repeated every 3 to 6 weeks.
Usual Pediatric Dose for Testicular Cancer:
For use in the treatment of metastatic nonseminomatous testicular cancer: 1000 mcg/m2 intravenously on day 1 as part of a combination regimen with cyclophosphamide, bleomycin, vinblastine, and cisplatin.
Usual Pediatric Dose for Trophoblastic Disease:
For use in the treatment of gestational trophoblastic neoplasia: 12 mcg/kg intravenously daily for five days as a single agent. or 500 mcg intravenously on days 1 and 2 as part of a combination regimen with etoposide, methotrexate, folinic acid, vincristine, cyclophosphamide and cisplatin.
Usual Pediatric Dose for Malignant Disease:
For use as a component of regional perfusion in the palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies: 50 mcg/kg for lower extremity or pelvis or 35 mcg/kg for upper extremity. (Please note that the dosage schedules and the technique itself vary from one investigator to another. Please consult the published literature for details.)
Usual Pediatric Dose for Osteosarcoma:
600 mcg/m2/day on days 1, 2, and 3 as part of a combination chemotherapy regimen
What other drugs will affect dactinomycin?
Other drugs may interact with dactinomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.