Onglyza 2.5 mg Tablet

Onglyza 2.5 mg (Saxagliptin)

Uses of Onglyza 2.5 mg (Saxagliptin)

Onglyza 2.5 mg is used to treat type-2 diabetes mellitus (T2DM) not controlled by diet and exercise alone and in whom metformin cannot be given due to contradiction or intolerance. If diabetes is not adequately controlled by insulin or other oral antidiabetic medicines (metformin, thiazolidinedione or sulphonylurea) or their combination, then Onglyza 2.5 mg can be used in a dual or triple medicine combination.

How it works

Onglyza 2.5 mg is an oral antidiabetic belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It acts by inhibiting the enzyme (dipeptidyl peptidase-4 (DPP-4)) which prevents the breakdown of substances called as incretins, ultimately increasing the production of insulin that reduces blood glucose level at fasting and after intake of food.

What is saxagliptin?

Saxagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. It is for people with type 2 diabetes. Saxagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. It may also be used for purposes not listed in this medication guide.

What is the most important information I should know about saxagliptin?

You should not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Saxagliptin is not for treating type 1 diabetes.

What should I discuss with my healthcare provider before taking saxagliptin?

You should not use this medication if you have ever had a severe allergic reaction to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take saxagliptin, tell your doctor if you have:

• Kidney disease (or if you are on dialysis);
• Heart disease;
• Pancreatitis;
• Gallstones;
• High triglycerides (a type of fat in the blood); or
• A history of alcoholism.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether saxagliptin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Saxagliptin is not approved for use by anyone younger than 18 years old.

How should I take saxagliptin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food. Follow your doctor?s instructions. Do not crush, chew, or break a saxagliptin tablet. Swallow it whole.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor?s office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Do not change your medication dose or schedule without your doctor?s advice.

Your doctor may want you to stop taking saxagliptin for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

Saxagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store at room temperature away from moisture and heat

What happens if I miss a dose?

Take the missed dose as soon as you remember (be sure to take the medicine with food if your doctor has instructed you to). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention. You may have signs of low blood sugar, such as extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What should I avoid while taking saxagliptin?

Follow your doctor?s instructions about any restrictions on food, beverages, or activity.

Common side effects

• Nausea,
• Rash,
• Abdominal pain,
• Allergic reaction,
• Diarrhoea,
• Dizziness,
• Fatigue,
• Gastroenteritis,
• Headache,
• Urinary tract infection,
• Vomiting,
• Sore throat

Expert Advice for Onglyza

Do not start or continue saxagliptin and consult your doctor:

• If you have allergy to saxagliptin.
• If you have type 1 diabetes or if you have serious complication of diabetes where high levels of blood acids called ketones are produced in your body (diabetic ketoacidosis).
• If you are taking insulin or other antidiabetic drug known as a sulphonylurea, your doctor may reduce the dose of your medicines, as it may otherwise cause excessively low blood glucose (hypoglycemia).
• If you have severe liver disease, kidney disease or heart failure.
• If you suffer from a disease like AIDS or have undergone organ transplant.
• If you have or have had a disease of the pancreas.
• If you are taking, have recently taken or might take any other medicines for treatment of fits, chronic pain, any infection, or high blood pressure.
• Do not substitute it with insulin, if you are on insulin.

FAQs

Saxagliptin

Q: Does saxagliptin/Onglyza cause weight loss/ weight gain?
A: Onglyza is the trade name for saxagliptin. Saxagliptin/Onglyza does not cause weight loss/reduction. Saxagliptin/ Onglyza does not cause any apparent change in body weight.

Q: Does Kombiglyze cause weight loss (reduction)?
A: Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Weight loss is one of the side effect of Kombiglyze; the metformin component present in Kombiglyze may be responsible for the same. Please note, Kombiglyze is not a weight-loss drug.

Q: Does saxagliptin/Kombiglyze cause constipation?
A: Kombiglyze is trade name for the combination of medicines saxagliptin and metformin.. Saxagliptin/Kombiglyze does not cause constipation.

Q: Does saxagliptin/ Kombiglyze cause diarrhea?
A: Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/ Kombiglyze may cause diarrhea.

Q: Does saxagliptin/Kombiglyze cause hair loss?
A: Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/Kombiglyze does not cause hair loss.

Q: Does Onglyza have a generic?
A: Onglyza is the trade name of the active drug saxagliptin. Saxagliptin is not available in a generic form.

Q: Does Onglyza contain metformin?
A: No. It only contains saxagliptin as an active drug.

Q: Does saxagliptin/Onglyza/ Kombiglyze cause cancer?
A: Onglyza is a trade name for medicine saxagliptin. Kombiglyze is trade name for the combination of medicines saxagliptin and metformin. Saxagliptin/Onglyza/ Kombiglyze has neither reported to cause any cancer, nor has any potential to cause cancer.

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